Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0

Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
Author :
Publisher : MDPI
Total Pages : 286
Release :
ISBN-10 : 9783036502564
ISBN-13 : 3036502564
Rating : 4/5 (64 Downloads)

Book Synopsis Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 by : Patrick M. Dansette

Download or read book Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 written by Patrick M. Dansette and published by MDPI. This book was released on 2021-08-31 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.


Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 Related Books

Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
Language: en
Pages: 286
Authors: Patrick M. Dansette
Categories: Science
Type: BOOK - Published: 2021-08-31 - Publisher: MDPI

DOWNLOAD EBOOK

This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three re
Reactive Drug Metabolites
Language: en
Pages: 445
Authors: Amit S. Kalgutkar
Categories: Medical
Type: BOOK - Published: 2012-09-06 - Publisher: John Wiley & Sons

DOWNLOAD EBOOK

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmace
ADME Processes in Pharmaceutical Sciences
Language: en
Pages: 364
Authors: Alan Talevi
Categories: Medical
Type: BOOK - Published: 2018-11-30 - Publisher: Springer

DOWNLOAD EBOOK

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy fo
The Biochemistry of Drug Metabolism
Language: en
Pages:
Authors: Bernard Testa
Categories:
Type: BOOK - Published: 2008 - Publisher:

DOWNLOAD EBOOK

Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an
Activation and Detoxification Enzymes
Language: en
Pages: 185
Authors: Chang-Hwei Chen
Categories: Medical
Type: BOOK - Published: 2011-11-16 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

Humans are exposed to foreign compounds such as drugs, household products and environmental chemicals by swallowing or breathing. Also, food is considered a for