Mitochondrial DNA Mutations in Aging, Disease and Cancer

Mitochondrial DNA Mutations in Aging, Disease and Cancer
Author :
Publisher : Springer Science & Business Media
Total Pages : 417
Release :
ISBN-10 : 9783662125090
ISBN-13 : 3662125099
Rating : 4/5 (90 Downloads)

Book Synopsis Mitochondrial DNA Mutations in Aging, Disease and Cancer by : Keshav K. Singh

Download or read book Mitochondrial DNA Mutations in Aging, Disease and Cancer written by Keshav K. Singh and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.


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