Download or read book Molecular Methods for Antimicrobial Resistance (AMR) Diagnostics to Enhance the Global Antimicrobial Resistance Surveillance System written by and published by . This book was released on 2019 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2015, WHO launched the Global Antimicrobial Resistance Surveillance System (GLASS) in order to standardize the collection of data on antimicrobial resistance (AMR) in Member States, for planning, prevention and intervention programmes. Reports to GLASS currently rely on detection of phenotypic resistance, which requires bacteria to be cultured and tested for growth in the presence of antimicrobial agents. In future, GLASS may incorporate the results of molecular testing for AMR detection by appropriate methods. Molecular diagnostic methods can be used at the same time as phenotypic testing to yield additional information, such as the exact gene or mutation underlying a resistance phenotype. This information can be used to interpret AMR profiles at surveillance sites and better understand the global occurrence of certain resistance mechanisms. Of the available molecular methods, fully automated, integrated, cartridge-operated polymerase chain reaction (PCR) or loop-mediated isothermal amplification (LAMP) devices and lateral flow assays are the most suitable for laboratories with no previous experience in molecular testing in AMR surveillance. The document also provides a review of available methods and how they could be used in national surveillance.