Clinical Trial Design

Clinical Trial Design
Author :
Publisher : John Wiley & Sons
Total Pages : 368
Release :
ISBN-10 : 9780470581711
ISBN-13 : 0470581719
Rating : 4/5 (11 Downloads)

Book Synopsis Clinical Trial Design by : Guosheng Yin

Download or read book Clinical Trial Design written by Guosheng Yin and published by John Wiley & Sons. This book was released on 2012-01-03 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.


Clinical Trial Design Related Books

MACK'S CRIMINAL LAW TRIAL BOOK
Language: en
Pages:
Authors: DALLAS. MACK
Categories:
Type: BOOK - Published: 2020 - Publisher:

DOWNLOAD EBOOK

Rap on Trial
Language: en
Pages: 223
Authors: Erik Nielson
Categories: Social Science
Type: BOOK - Published: 2019-11-12 - Publisher: The New Press

DOWNLOAD EBOOK

A groundbreaking exposé about the alarming use of rap lyrics as criminal evidence to convict and incarcerate young men of color Should Johnny Cash have been ch
Complete Collection of State Trials
Language: en
Pages: 1154
Authors: Francis Hargrave
Categories:
Type: BOOK - Published: 1795 - Publisher:

DOWNLOAD EBOOK

Clinical Trial Design
Language: en
Pages: 368
Authors: Guosheng Yin
Categories: Medical
Type: BOOK - Published: 2012-01-03 - Publisher: John Wiley & Sons

DOWNLOAD EBOOK

A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest an
A Complete Collection of State Trials and Proceedings for High Treason and Other Crimes and Misdemeanors from the Earliest Period to the Year 1783
Language: en
Pages: 784
Authors: Thomas Bayly Howell
Categories: Law reports, digests, etc
Type: BOOK - Published: 1816 - Publisher:

DOWNLOAD EBOOK