Anticancer Agents from Natural Products, Second Edition

Anticancer Agents from Natural Products, Second Edition
Author :
Publisher : CRC Press
Total Pages : 786
Release :
ISBN-10 : 9781439813829
ISBN-13 : 1439813825
Rating : 4/5 (29 Downloads)

Book Synopsis Anticancer Agents from Natural Products, Second Edition by : Gordon M. Cragg

Download or read book Anticancer Agents from Natural Products, Second Edition written by Gordon M. Cragg and published by CRC Press. This book was released on 2011-10-10 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.


Anticancer Agents from Natural Products, Second Edition Related Books

Anticancer Agents from Natural Products, Second Edition
Language: en
Pages: 786
Authors: Gordon M. Cragg
Categories: Science
Type: BOOK - Published: 2011-10-10 - Publisher: CRC Press

DOWNLOAD EBOOK

The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natu
Anticancer Agents from Natural Products
Language: en
Pages: 610
Authors: Gordon M. Cragg
Categories: Medical
Type: BOOK - Published: 2005-06-13 - Publisher: CRC Press

DOWNLOAD EBOOK

Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and pr
Medicinal Chemistry of Anticancer Drugs
Language: en
Pages: 767
Authors: Carmen Avendaño
Categories: Science
Type: BOOK - Published: 2015-06-11 - Publisher: Elsevier

DOWNLOAD EBOOK

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing o
Chemistry and Pharmacology of Anticancer Drugs
Language: en
Pages: 619
Authors: David E. Thurston
Categories: Medical
Type: BOOK - Published: 2021-03-17 - Publisher: CRC Press

DOWNLOAD EBOOK

While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effective
Discovery and Development of Anti-Breast Cancer Agents from Natural Products
Language: en
Pages: 386
Authors: Goutam Brahmachari
Categories: Science
Type: BOOK - Published: 2021-06-24 - Publisher: Elsevier

DOWNLOAD EBOOK

Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products