Download or read book Function of an Androgen Receptor Coactivator Regulated in Prostate Development and Prostate Cancer written by and published by . This book was released on 2005 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: We hypothesize that ART-27 affects AR-dependent differentiation of prostate epithelial cells by regulating a subset of AR responsive genes important to prostate growth suppression and differentiation. We further hypothesize that alterations in the level of ART-27 modulates AR activity, which, in turn, affects AR-dependent cell growth regulation in vivo. Our aims are to identify ART-27-dependent AR-target genes involved in growth suppression and differentiation and to elucidate the mechanism of regulation of ART-27 expression in prostate cancer. Our approach is to ablate ART-27 protein using siRNA technology followed by gene expression array. Our preliminary findings indicate that loss of ART-27 may result in enhanced expression of genes that are often over-expressed in prostate cancer such as PSA, FKBP5, SOR, KRT18, and CDKN3. Loss of ART-27 also shows enhanced expression of at least one positive regulator of tumor growth, CDKN3.