Tumor Suppressor Par-4

Tumor Suppressor Par-4
Author :
Publisher : Springer Nature
Total Pages : 329
Release :
ISBN-10 : 9783030805586
ISBN-13 : 3030805581
Rating : 4/5 (86 Downloads)

Book Synopsis Tumor Suppressor Par-4 by : Vivek M. Rangnekar

Download or read book Tumor Suppressor Par-4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.


Tumor Suppressor Par-4 Related Books

Tumor Suppressor Par-4
Language: en
Pages: 329
Authors: Vivek M. Rangnekar
Categories: Medical
Type: BOOK - Published: 2022-01-01 - Publisher: Springer Nature

DOWNLOAD EBOOK

Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving
Molecular Biology of Prostate Cancer
Language: en
Pages: 220
Authors: Manfred Wirth
Categories: Medical
Type: BOOK - Published: 2013-05-22 - Publisher: Walter de Gruyter

DOWNLOAD EBOOK

How Tobacco Smoke Causes Disease
Language: en
Pages: 728
Authors: United States. Public Health Service. Office of the Surgeon General
Categories: Government publications
Type: BOOK - Published: 2010 - Publisher:

DOWNLOAD EBOOK

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have conside
Tumor Suppressor Par-4
Language: en
Pages: 328
Authors: Vivek M. Rangnekar
Categories: Medical
Type: BOOK - Published: 2022-01-08 - Publisher: Springer Nature

DOWNLOAD EBOOK

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis.
Adenocarcinoma of the Prostate
Language: en
Pages: 363
Authors: Andrew W. Bruce
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the pre