Download or read book Science of Synthesis: C-1 Building Blocks in Organic Synthesis Vol. 1 written by Piet W.N.M. van Leeuwen and published by Thieme. This book was released on 2014-05-14 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set on C-1 Building Blocks in Organic Synthesis critically reviews the state of the art of a wide variety of reactions by which one carbon atom is added to an organic molecule, forming a C-C bond. In spite of the numerous classic reactions of this kind, there has been enormous progress in recent years, especially for those reactions involving catalytic methods. Introduction of substituted methyl groups is a major challenge and only very recently the first catalysts have been discovered that enable the introduction of fluoromethyl groups in aromatics.