Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones
Author | : Robert Doran |
Publisher | : Springer |
Total Pages | : 218 |
Release | : 2015-06-24 |
ISBN-10 | : 9783319205441 |
ISBN-13 | : 3319205447 |
Rating | : 4/5 (41 Downloads) |
Download or read book Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones written by Robert Doran and published by Springer. This book was released on 2015-06-24 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.