Clinical and Statistical Considerations in Personalized Medicine

Clinical and Statistical Considerations in Personalized Medicine
Author :
Publisher : CRC Press
Total Pages : 368
Release :
ISBN-10 : 9781466593879
ISBN-13 : 1466593873
Rating : 4/5 (79 Downloads)

Book Synopsis Clinical and Statistical Considerations in Personalized Medicine by : Claudio Carini

Download or read book Clinical and Statistical Considerations in Personalized Medicine written by Claudio Carini and published by CRC Press. This book was released on 2014-03-27 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.


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