Download or read book CLINICAL REVIEW ARTICLES IN PHYSIO PHARMACOLOGY VOLUME V written by Dr. Ambika Prasad Khadanga Mahapatra, Dr. E. Muralinath, Dr. E. Sony Sharlet and Dr. M. Guru Prasad and published by Laxmi Book Publication. This book was released on 2024-06-07 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: ACT Heart failure remains a significant health challenge globally, influencing millions of individuals and imposing a considerable burden on healthcare systems. Factors influencing heart failure include Cardiac remodeling, neuro hormonal activation, impaired contractility as well as ejection fraction, ventricular dysfunction as well as chamber dilation, inflammatory as well as oxidative stress, endothelial dysfunction and microbial dysfunction. Finally it is concluded that heart failure is a complex syndrome resulting from multiple pathophysiological mechanisms.