Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction
Author :
Publisher : Springer Science & Business Media
Total Pages : 384
Release :
ISBN-10 : 9789048198818
ISBN-13 : 904819881X
Rating : 4/5 (18 Downloads)

Book Synopsis Mechanosensitivity and Mechanotransduction by : Irina Kiseleva

Download or read book Mechanosensitivity and Mechanotransduction written by Irina Kiseleva and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.


Mechanosensitivity and Mechanotransduction Related Books

Mechanosensitivity and Mechanotransduction
Language: en
Pages: 384
Authors: Irina Kiseleva
Categories: Science
Type: BOOK - Published: 2010-11-18 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity
Mechanosensitive Ion Channels
Language: en
Pages: 390
Authors: Andre Kamkin
Categories: Science
Type: BOOK - Published: 2007-10-06 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists
Piezo Channels
Language: en
Pages: 350
Authors:
Categories: Science
Type: BOOK - Published: 2017-07-17 - Publisher: Academic Press

DOWNLOAD EBOOK

Piezo Channels, Volume 79, the latest volume in the Current Topics in Membranes series provides the necessary membrane research to assist readers in discovering
Mechanical Stretch and Cytokines
Language: en
Pages: 247
Authors: Andre Kamkin
Categories: Science
Type: BOOK - Published: 2011-09-06 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of diff
Mechanosensitivity of the Nervous System
Language: en
Pages: 355
Authors: Andre Kamkin
Categories: Science
Type: BOOK - Published: 2008-09-22 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This book presents the latest findings in mechanosensitivity of the nervous system. The nervous system stands out from a number of tissues because besides react