Myeloid Derived Suppressor Cells as Disease Modulators

Myeloid Derived Suppressor Cells as Disease Modulators
Author :
Publisher : Frontiers Media SA
Total Pages : 162
Release :
ISBN-10 : 9782889636778
ISBN-13 : 2889636771
Rating : 4/5 (78 Downloads)

Book Synopsis Myeloid Derived Suppressor Cells as Disease Modulators by : Olivera J. Finn

Download or read book Myeloid Derived Suppressor Cells as Disease Modulators written by Olivera J. Finn and published by Frontiers Media SA. This book was released on 2020-05-06 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of immature myeloid cells that can suppress the function of multiple immune cells and in particular, T cells, through various mechanisms. MDSCs can be divided into two major subtypes based on their cell surface phenotype and morphology: polymorphonuclear MDSC (PMN-MDSC or G-MDSC) and monocytic MDSC (M-MDSC). Additional subtypes have been proposed, such as the early MDSC (e-MDSC) that lack both macrophage and granulocyte markers. There is still considerable ambiguity about the phenotype of these cells that corresponds to their immunosuppressive function and there are on-going challenges on how to identify, purify and/or potentially generate and expand these cells in vitro. MDSCs were first discovered in cancer patients where they have been most extensively studied as components of the immunosuppressive tumor microenvironment. In the last several years, however, the importance of their immunomodulatory role in many other disease and clinical settings has emerged. Acknowledgments We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.


Myeloid Derived Suppressor Cells as Disease Modulators Related Books

Myeloid Derived Suppressor Cells as Disease Modulators
Language: en
Pages: 162
Authors: Olivera J. Finn
Categories:
Type: BOOK - Published: 2020-05-06 - Publisher: Frontiers Media SA

DOWNLOAD EBOOK

Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of immature myeloid cells that can suppress the function of multiple immune cells and in
Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy
Language: en
Pages: 271
Authors: Pawel Kalinski
Categories: Medical
Type: BOOK - Published: 2017-12-22 - Publisher: Springer

DOWNLOAD EBOOK

The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the
Handbook on Immunosenescence
Language: en
Pages: 1693
Authors: Tamas Fulop
Categories: Medical
Type: BOOK - Published: 2009-02-27 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and
Interaction of Immune and Cancer Cells
Language: en
Pages: 268
Authors: Magdalena Klink
Categories: Medical
Type: BOOK - Published: 2013-11-26 - Publisher: Springer Science & Business Media

DOWNLOAD EBOOK

The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and recepto
Translational Immunotherapy of Brain Tumors
Language: en
Pages: 406
Authors: John H. Sampson
Categories: Medical
Type: BOOK - Published: 2017-02-06 - Publisher: Academic Press

DOWNLOAD EBOOK

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive