Download or read book Phosphoinositide 3-kinase in Health and Disease written by Christian Rommel and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target