Download or read book Systematic Review of Luteinising Hormone-releasing Hormone Agonists in Adjuvant Therapy of Early Breast Cancer written by Rohini Sharma and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Luteinising hormone-releasing hormone (LHRH) agonists provide effective ovarian suppression in pre-menopausal women and have been shown to be an acceptable alternative to ovarian ablation by surgery or radiotherapy. In contrast to surgical or radiological methods, LHRH agonists induce a menopausal status that is reversible on cessation of treatment. The objectives were to review trials in which LHRH agonists have been: integrated into adjuvant hormonal therapy; integrated into adjuvant chemo-hormonal therapy; and compared with ovarian ablation by surgery or radiotherapy.