Download or read book The Role of Nuclear Receptor Coactivators in Recurrent Prostate Cancer written by and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothesis for this proposal is that in a substantial number of recurrent prostate cancers, growth is driven by the overexpression of steroid receptor coactivators SRC1 and TlF2 through their effects on AR-mediated gene expression. Completion of the studies proposed will elucidate the role of nuclear receptor coactivators in the progression of prostate cancer from the androgen-dependent to the recurrent state. We will test the hypothesis that recurrent prostate cancer growth is driven by the overexpression of coactivators SRCl and TIF2 through their effects on AR-mediated gene expression. By completing studies on coactivator expression in prostate cancer specimens, coactivator phosphorylation and the kinase signaling pathways responsible, we will establish a link between AR function as a part of the transcription complex and cell growth in recurrent prostate cancer.